![]() Patient presents within 1-2 hours of ingestion (which rarely happens).(4) Peripheral vasodilators (betaxolol, bucindolol, carteolol, carvedilol, celiprolol, labetalol, nebivolol) may cause hypotension due partially to peripheral vasodilation.(3) Cardiac potassium channel blockade (acebutolol, sotalol) may prolong the QTc and cause torsade de pointes.Hypotension can be more severe than one would expect, based solely on the degree of bradycardia. (2) Cardiac sodium channel blockade (acebutolol, betaxolol, carvedilol, oxprenolol, pindolol, propranolol) – may cause QRS widening and monomorphic VT.(1) Lipophilic agents (e.g., propranolol) are more likely to enter the brain and cause delirium or seizure.Higher doses: will affect heart as well (vasodilation combined with bradycardia).Lower doses: can cause a primarily vasodilatory shock state (hypotension with reflex tachycardia).However, at high doses they lose selectivity for the vasculature and suppress the myocardium. Dihydropyridine CCBs (e.g., nifedipine, isradipine, amlodipine, felodipine, nimodipine) initially cause vasodilation.Presentation is marked by early development of hypotension and bradycardia. ![]()
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